Live Event Content · 2025 Pediatric Surgery Update Course - Updates in NEC Management
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Video26 min·Published Aug 2025

2025 Pediatric Surgery Update Course - Updates in NEC Management

hosted by Dr. Todd Ponsky
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What the experts said20 expert statements · 3 host summaries
Abdominal X-rays for NEC have high specificity but very low sensitivity, with studies showing sensitivity between 13 and 25%
ClinicalTodd Ponsky
Ultrasound can detect bowel wall thickening, thinning, perfusion, peristalsis, and peritoneal and hepatic findings that X-ray cannot
ClinicalTodd Ponsky
Ultrasound is indicated when the neonate does not appear to have NEC and X-ray is equivocal, in early stages of NEC when X-ray sensitivity is very low, or when the baby is very sick and X-ray does not match clinical scenario
ClinicalTodd Ponsky
High-risk ultrasound findings for bowel perforation include pneumoperitoneum, focal fluid collections, and complex free fluid
ClinicalTodd Ponsky
Intermediate-risk ultrasound findings include increased bowel wall echogenicity, absent perfusion, portal venous gas, and bowel thinning or thickening; the more of these present, the more likely surgical intervention is needed
ClinicalTodd Ponsky
NEC is a progressive disease; the bowel is a symptom or result of the illness, not the cause, and the disease can still progress even after resection
Clinical
Spontaneous intestinal perforation is totally different from NEC and was an exclusion criterion for the trial
ClinicalTodd Ponsky
Pancolitis represents the other end of the spectrum where you cannot do an anastomosis
Clinical
At Great Ormond Street Hospital, primary anastomosis has been the operative choice for quite some time under the guidance of Mr. Kiely, Professor Spitz, and Agostino Pierro
ClinicalSimon
The RCT used intraoperative randomization, with consent obtained preoperatively but final eligibility determined by surgeon's judgment during laparotomy after examining the bowel
ClinicalSimon
Infants with very small perforations (spontaneous intestinal perforation) where no one would realistically do a stoma, and those with very extensive disease where no one would want to do primary anastomosis, were excluded from randomization
ClinicalSimon
More than 20 babies were randomized intraoperatively by the speaker for the trial; randomization involved unscrubbing and going to the computer during the operation
Clinical
The trial was never going to be powered for mortality or neurodevelopmental outcomes, so time on parenteral nutrition was chosen as the primary outcome
ClinicalSimon
The primary outcome of the RCT was time on parenteral nutrition; those who had primary anastomosis got onto full enteral feeds sooner and finished parenteral nutrition earlier
ClinicalSimon
There was no significant difference in mortality between primary anastomosis and stoma groups; if anything, mortality was slightly higher in the stoma group but not significantly different
ClinicalSimon
Stoma complications were inevitably present in the stoma group; there were some complications in the primary anastomosis group, but overall complications were worse in the stoma group
ClinicalSimon
The trial conclusions were that primary anastomosis led to reduced duration of parenteral nutrition, reduced intestinal complications, and no difference in mortality
ClinicalSimon
A randomized controlled trial of mucus fistula refeeding is ongoing, with time to full enteral feeds as the primary outcome; most of the population is NEC but includes other neonates with bowel resection
ClinicalSimon
Exclusion from the trial was mainly upfront when parents did not want to give consent due to distress; intraoperatively, those with focal intestinal perforation and instability, pancolitis, or distal colonic disease were not considered
Clinical
Radiologists can detect perforation by ultrasound even when not visible on plain film; some babies will have clear evidence of perforation at operation that was missed on X-ray but detected by ultrasound
Clinical
A 2017 meta-analysis highlighted potential advantages of primary anastomosis compared to stoma but concluded that a randomized controlled trial was necessary due to lack of RCT evidence and potential differences in disease severity between groups
Host summarySimon summarizing the discussion · not cited in answers
Evidence for mucus fistula refeeding is not strong based on a systematic review and meta-analysis by Bonnie Gisani from Toronto SickKids
Host summarySimon summarizing the discussion · not cited in answers
A recent paper in Journal of Surgical Research showed that early stoma closure (less than 8 weeks) appears safe, but the study is underpowered and concerning because two infants had repeat episodes of NEC
Host summarySimon summarizing the discussion · not cited in answers