Social Determinants of Health Influence on Survival in Wilms Tumor, Neuroblastoma, and Hepatoblastoma

Study was a retrospective analysis of 12,000 patients with neuroblastoma, Wilms tumor, and hepatoblastoma from the National Cancer Database

Socioeconomic disadvantage score was created for each patient based on median household income and education level in their local communities

The most disadvantaged children were more likely to have worse survival for Wilms tumor and neuroblastoma

After adjusting for tumor size, grade, treatment, and comorbidities, socioeconomic effects on survival remained present

Hazard ratio for socioeconomic disadvantage was 2.02 for Wilms tumor

Hazard ratio for socioeconomic disadvantage was 1.29 for hepatoblastoma

Pediatric oncology outcomes depend on tumor biology, treatment received, and social determinants of health

Identifying socioeconomic risk factors is necessary to close equity gaps and improve survival for all children with solid tumors