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Updated Favorable histology Wilms tumor risk stratification: Rationale for future Children’s Oncology Group clinical trials
hosted by Dr. Jill Knepprath
Educational content from recorded physician discussions — not medical advice. Talk to your (or your child's) care team about your situation.
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What the experts said
Risk stratification for Wilms tumor has evolved many times over the years.
The Children's Oncology Group published updated risk stratification for patients with favorable histology Wilms tumor in Nature in June 2025.
The new risk stratification model includes biological and clinical features that were not in the first generation risk stratification.
The new model changes some of the older features or gets rid of them altogether.
Factors being added are loss of heterozygosity of 11P15, 1Q gain, and lymph node involvement.
Tumor nephrectomy weight is no longer included in the risk stratification.
The model modified how histology and age are used to stratify certain patients.
More changes are expected in the future as ongoing COG trials produce more results.