Utility of Fluorescence In Situ Hybridization as a Fetal Surgery Eligibility Criterion for....

Many centers require genetic testing to rule out chromosome abnormalities before fetal surgery, even when ultrasounds and blood tests already look reassuring

A study reviewed nearly 1000 pregnancies evaluated for fetal surgery

When imaging and cell-free DNA screening showed low risk for aneuploidy, the FISH test matched those results 100% of the time

For low-risk pregnancies, FISH did not provide any new information that changed surgery candidacy

In carefully selected low-risk cases, non-invasive screening may be enough, potentially avoiding the FISH procedure