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Update Course Rewind: Staging and Management of Neuroblastoma 2022
With Dr. Paul Yasurjak
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What the experts said
The presented case is a 16-month-old with a right adrenal mass measuring 8 centimeters
Biopsy showed favorable cell neuroblastoma biology with no MYCN amplification but with segmental chromosomal abnormalities
The Children's Oncology Group neuroblastoma classification tree is constantly changing as new information is added
Based on the 2021 COG classification, the presented tumor would be classified as higher risk
COG reviewed patients enrolled in trials between 2007 and 2017
The presence of segmental chromosomal aberrations such as loss or gain of a portion of the chromosomal arm can have a negative impact on patient outcomes
The updated schema classifies tumors as high risk when there is no MYCN amplification but segmental chromosomal abnormalities are present