Infographic: Survival in children with hepatoblastoma and pulmonary metastatic disease at diagnosis based on extent of metastases and need for surgical clearance
Topic overview
Multicenter study of 62 children with metastatic hepatoblastoma shows long-term survival is achievable regardless of pulmonary disease extent. Combination of chemotherapy and surgical metastasectomy successfully cleared lung metastases in 95% of patients, with similar outcomes whether disease was limited or extensive at diagnosis.
Key takeaways
- Children with hepatoblastoma and pulmonary metastases can achieve long-term survival regardless of metastatic burden extent (>10 vs ≤10 lesions).
- 95% of patients achieved pulmonary metastasis clearance through chemotherapy alone (54%) or combined with metastasectomy (46%), with similar survival outcomes.
- Extensive pulmonary disease (>10 metastases) does not preclude curative treatment; aggressive multimodal therapy including metastasectomy is warranted.
- All liver transplant recipients who underwent surgical clearance of metastatic disease were alive at follow-up, supporting aggressive surgical management.
- Neoadjuvant chemotherapy combined with metastasectomy effectively clears pulmonary disease and enables long-term disease-free survival in metastatic hepatoblastoma.
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