Pancreatitis in Pediatric Patients with Pancreatic Solid Pseudopapillary Neoplasms: A Single Center Experience

Topic overview

Single-center study of 10 female pediatric patients with solid pseudopapillary neoplasms found that all who developed post-operative pancreatitis had either hereditary gene mutations (CFTR variants, PRSS1 duplication) or anatomic abnormalities (pancreas divisum). Findings suggest genetic and anatomic evaluation prior to resection may help predict post-operative outcomes in this rare pediatric population.

Key takeaways

All pediatric SPN patients who developed post-op pancreatitis had pancreatic head lesions and genetic/anatomic risk factors (CFTR variants or divisum).
Pre-operative genetic testing and anatomic evaluation may predict post-operative ARP/CP risk in pediatric SPN resection candidates.
Three of ten patients required completion pancreatectomy with islet autotransplantation, highlighting need for multidisciplinary planning.
EUS was performed in only half of cases; standardized pre-op imaging protocols may improve surgical planning and outcomes.
Pediatric SPN resection requires coordinated care between surgery, genetics, and gastroenterology to optimize long-term pancreatic function.

Keywords

Solid Pseudopapillary Neoplasm Pediatric Pancreatitis Pancreatic Surgery Cftr Variants Pancreaticoduodenectomy Islet Autotransplantation Pancreas Divisum

Hashtags

#PediatricPancreas #SolidPseudopapillaryNeoplasm #PancreatitisGenetics #PediatricSurgery #PediatricPancreatitis #PancreaticNeoplasm #IsletAutotransplantation #CFTRVariants

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