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- Slide 1: Oncology | Expert-to-Expert | Made possible by Cincinnati Children's | A 1-year-old with anemia on routine labs and a right-sided abdominal mass. Diagnosis: SCCOHT, the most aggressive ovarian tumor. HIPEC is part of the plan. | DOES IT GO BEFORE CHEMOTHERAPY, OR AFTER? | 1/6
- Slide 2: Oncology | Clinical Foundations | Made possible by Cincinnati Children's | THE ANSWER: CHEMOTHERAPY FIRST | THE WINDOW OF CHEMOSENSITIVITY IS SHORT | SCCOHT responds to chemotherapy, but only transiently. | Intensive systemic therapy starts right away, ahead of any further staging or second-look surgery. | 2/6
- Slide 3: Oncology | Clinical Foundations | Made possible by Cincinnati Children's | THE SEQUENCE | HIPEC COMES AFTER THE CHEMOTHERAPY | SYSTEMIC CHEMO → CYTO-REDUCTION → HIPEC (CISPLATIN) → STEM CELL RESCUE | Surgery removes what chemotherapy leaves, heated cisplatin treats the peritoneal surfaces, and autologous stem cell rescue follows. | 3/6
- Slide 4: Oncology | Clinical Foundations | Made possible by Cincinnati Children's | WHAT CHANGES IN A CHILD THIS SMALL | Roshni Dasgupta, MD, MPH | Professor, Director Surgical Oncology, Cincinnati Children's | 4/6
- Slide 5: Oncology | Clinical Foundations | Made possible by Cincinnati Children's | THE TAKEAWAY | CHEMOTHERAPY FIRST, WHILE THE WINDOW IS OPEN | HIPEC and stem cell rescue remain an institutional approach in SCCOHT, with limited evidence and wide variation between centers. | Whatever comes next, systemic therapy starts now. | 5/6
- Slide 6: Oncology | Clinical Foundations | Made possible by Cincinnati Children's | FOLLOW FOR MORE PEDIATRIC SURGERY EDUCATION. | 6/6
SCCOHT and HIPEC: Before or After Chemotherapy?
Topic overview
Educational carousel addressing the optimal timing of hyperthermic intraperitoneal chemotherapy (HIPEC) in relation to systemic chemotherapy for small cell carcinoma of the ovary, hypercalcemic type (SCCOHT). Explores treatment sequencing considerations in this rare pediatric malignancy.
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