Mucous fistula refeeding in neonates: a systematic review and meta-analysis
Topic overview
Systematic review of 16 studies (n=623) shows mucous fistula refeeding reduces parenteral nutrition duration by 37 days in neonates with ostomies, while also decreasing cholestasis rates and hospital stay. This technique maintains intestinal physiology by reintroducing proximal effluent into the distal limb after abdominal surgery.
Key takeaways
- Mucous fistula refeeding reduces parenteral nutrition duration by ~37 days in neonates with ostomies after abdominal surgery.
- MFR maintains intestinal physiology by reintroducing proximal ostomy effluent into the distal mucous fistula.
- Neonates receiving MFR show lower cholestasis rates, faster time to full enteral feeds, and shorter hospital stays.
- Current evidence is low certainty (observational studies only); randomized trials needed to confirm benefits.
- MFR is a practical strategy to optimize bowel function and reduce TPN dependence in neonates with temporary ostomies.
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