Efficacy and late kidney effects of nephron-sparing surgery in the management of unilateral Wilms tumor
Topic overview
Systematic review comparing nephron-sparing surgery to radical nephrectomy in unilateral Wilms tumor found NSS preserves renal function without compromising oncological outcomes. Meta-analysis of 10,979 patients showed NSS significantly improved eGFR at follow-up with similar survival and recurrence rates to radical nephrectomy.
Key takeaways
- Nephron-sparing surgery significantly increased eGFR at follow-up compared to baseline, while radical nephrectomy showed no significant change
- NSS and RN showed no significant differences in survival, recurrence, renal dysfunction, or hypertension rates in unilateral Wilms tumor
- Meta-analysis of 10,979 patients demonstrates NSS is safe and effective, preserving renal function without compromising oncologic outcomes
- Current evidence supports NSS as preferred approach for unilateral Wilms tumor when technically feasible
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