Eficacia y efectos renales tardíos de la cirugía conservadora de nefronas en el tratamiento del tumor de Wilms unilateral
Topic overview
Systematic review and meta-analysis comparing nephron-sparing surgery to radical nephrectomy in unilateral Wilms tumor demonstrates NSS preserves renal function without compromising oncological outcomes. Analysis of 10,979 patients shows NSS significantly improves eGFR at follow-up with similar survival and recurrence rates.
Key takeaways
- Nephron-sparing surgery (NSS) significantly improved eGFR at follow-up vs. diagnosis in unilateral Wilms tumor patients
- NSS showed similar survival and recurrence rates compared to radical nephrectomy, with no significant oncologic disadvantage
- Radical nephrectomy did not significantly decrease eGFR at follow-up, but NSS preserved renal function better overall
- No significant differences found in renal dysfunction or hypertension rates between NSS and radical nephrectomy approaches
- Current evidence supports NSS as safe and effective for unilateral Wilms tumor with superior renal outcomes
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