Resultados de la criopreservación de la fertilidad femenina en el cáncer infantil
Topic overview
Systematic review of ovarian tissue cryopreservation outcomes in 612 pediatric cancer patients across 7 countries found that 5.9% underwent tissue transplantation, with 33% achieving pregnancy and 67% resulting in live births. Study highlights need for long-term outcome data in pediatric populations, as current evidence predominantly reflects adult patients in high-income countries.
Key takeaways
- Ovarian tissue cryopreservation (OTC) is emerging as fertility preservation option for pediatric cancer patients facing gonadotoxic therapy
- Among 501 pediatric patients who underwent OTC, only 5.9% returned for ovarian tissue transplantation (OTT) in available follow-up data
- Of patients desiring pregnancy after OTT, 33% achieved pregnancy and 67% of those had live births, showing promising but limited outcomes
- Most cryopreservation outcome data comes from high-income countries and adult patients, highlighting need for long-term pediatric studies
- Standardized fertility preservation guidelines for pediatric cancer patients are needed to improve access across all income levels globally
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