Female Fertility Cryopreservation Outcomes in Childhood Cancer: A Systematic Review
Topic overview
This systematic review of 612 pediatric cancer patients across 7 countries found that while ovarian tissue cryopreservation is successfully performed, only 5.9% underwent transplantation, with 33% achieving pregnancy and 67% having live births. The study highlights critical gaps in long-term outcome data for prepubertal patients and calls for standardized fertility preservation protocols across all income levels.
Key takeaways
- OTC performed in 501 pediatric cancer patients; only 5.9% underwent transplantation, with 33% achieving pregnancy and 67% having live births
- Most common cancers requiring fertility preservation: hematological malignancies (81%), CNS tumors (56%), and sarcomas (39%)
- Long-term outcome data for pediatric OTC is lacking; most studies focus on adult patients in high-income countries
- Standardized fertility preservation guidelines needed for childhood cancer patients across all income levels
- OTC shows promise but requires longitudinal studies to establish efficacy in prepubertal and pediatric populations
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